CD8A and neoplasm: CY has a strong CD8 T cell-dependent anti-tumor effect in AB1-HA tumor-bearing mice, routinely leading to 75–100% cure rate when small (i.e., just palpable) tumors are treated (Figure 3A), confirming our previous data [18], whereas CD8 depletion alone had a weak effect accelarating tumor growth (P = 0.07, data not shown).