TIMP1 and neoplasm: However, in analyses of OS there was a statistically significant interaction between TIMP-1 and anthracycline treatment both in a model including only adjuvant therapy and TIMP-1 (HR 3.60, 95% CI 1.38-9.38, P = 0.009) and in the model including age, tumor size and malignancy grade (HR 3.20, 95% CI 1.26-8.12, P = 0.014).