Median tumor tissue TIMP-1 levels in subgroups according to adjuvant treatment were as follows: In CMF-treated patients 12.0 ng/mg of total protein (range, 0-106 ng/mg); in patients who received an anthracycline-containing regimen 13.5 ng/mg protein (range, 0-51.2 ng/mg); and in patients who received no adjuvant chemotherapy 13.8 ng/mg protein (range, 0-113 ng/mg). This evidence concerns the gene TIMP1 and neoplasm.