GK and Insulin resistance: However, adult Wistar and GK rats have similar α-cell mass and glucagonemia [125] and 100 mg/kg/day IL-1Ra in vivo did not modify GK glucagonemia (data not shown); 3) IL-1Ra appears less effective on insulin resistance at higher dose [52]; 4) the time of treatment onset, the dose and the duration of treatment could be improved; 5) TLR activation by FFA may be concomitantly at work in GK rats and IL-1Ra treatment did not modify circulating GK lipid parameters [52].