To address these gaps, the Treatment Related Impact Measure-Diabetes (TRIM-Diabetes), and the Treatment Related Impact Measure-Diabetes Device (TRIM-Device) measures, which capture the full range of impacts of diabetes treatment on patients' functioning and well-being across type 1 and type 2 diabetes, as well as across all currently available delivery systems and treatments (oral agents, GLP-1 pens, inhaled or pump delivered insulin and insulin delivered with syringe/pens) were developed. This evidence concerns the gene INS and diabetes mellitus.