PRNP and peripheral neuropathy: Transverse semithin sections of the sciatic nerve revealed peripheral neuropathy in Tg1046 PrP with axonal loss white arrows and myelin degeneration white arrowheads (Fig. 4H) but not in wt (Fig. 4F), PrPo/o (Fig. 4I) or Tg40 PrP (Fig. 4G) at 23 days of age.