Tg(Dpl)28272/ZrchI and (TgN-Dpl)32 mice, which express high amounts of Dpl, survived only 32 and 60 days respectively [18], [19] whereas mice expressing lower Dpl levels, such as PrnpNgsk/Ngsk mice [16], showed progressive symptoms of ataxia and were euthanized according to clinical scoring at ≥70 weeks of age. The gene discussed is PRND; the disease is Ataxia.