Using MUC4-knockdown and overexpression pancreatic cancer cell models, we have shown that MUC4 potentiates pancreatic tumour cell growth and metastasis by altering the behavioural properties of the tumour cells (Singh et al, 2004; Chaturvedi et al, 2007; Moniaux et al, 2007). Here, MUC4 is linked to familial pancreatic carcinoma.