FSCN1 and neoplasm: Hashimoto et al (2006) found altered fascin expression in colorectal adenomas, but found no difference in fascin expression between FAP and sporadic tumours. In the study presented here, we have assessed a cohort of adenomas for fascin expression and correlated these data with the size, histology and dysplasia in the tumours. These three characteristics are known to be related to one another, but are also thought to be the crucial criteria for determining the malignant potential of an adenoma (Hamilton and Aaltonen, 2001).