In addition, a combined analyses of 6 studies and 12 genes including imputed genotypes found evidence of association with selected SNPs in CDKN2A, CCND1, CDK2 and CCNE1, but not in CDKN2C, CDKN1A, CCND3, CCND2, CDKN1B, CDK4, RB1, CDKN2D or CDKN2B (Goode et al, 2009) Here, we report on a more comprehensive two-stage analysis of the association of ovarian cancer risk at 39 genes (288 SNPs) involved in G1/S and G2/M phases of the cell cycle and transcription- and ubiquitin-mediated degradation (Table 1). This evidence concerns the gene CDK2 and ovarian cancer.