Figure 4A shows the inhibitory effect of Ki23057 on the phosphorylation of gastric tumour specimens. VEGFR-3 phosphorylation was suppressed in the tumours of Ki23057-treated mice (mouse 2 and mouse 4) in comparison with that in the vehicle mice (mouse 1 and mouse 3). The tumours from the control mice that received vehicle only showed the strong staining of phosphotyrosine on the lymphatic endothelial cells of VEGFR-3 staining. In contrast, the tumours from mice that received Ki23057 showed weak staining of phosphotyrosine on the lymphatic endothelium (Figure 4B). The gene discussed is FLT4; the disease is neoplasm.