CSF3 and Decreased total neutrophil count: In a more recent randomised phase II study of the same group evaluating neoadjuvant TIP vs TP, aiming towards radical surgery in chemotherapy- and radiotherapy-naive patients, the incidence of grade 3–4 neutropenia was 76% for TIP vs 26% for TP without routine prophylactic G-CSF (Lissoni et al, 2009).