IGF2 and Familial prostate cancer: LOI of IGF2 gene is an important cause of biallelic expression of IGF2 and has been reported in many different types of tumors including osteosarcoma [16], lung adenocarcinomas [17], head and neck squamous cell adenocarcinomas [18], Wilms'tumor [7], prostate cancer [19], and colorectal carcinomas [20].