The type of mutations in the PARD3 gene in LNCaP cells, a base substitution resulting in nonsense codon in one allele and the deletion of a (T) in a (T)5 repeat in the other allele, suggests the selective advantage provided by the mutational inactivation of the gene; a repeat as short as (T)5 is stable even in cancers with MSI [22,23] and two independent mutations in a gene is a highly improbable event to occur without selection. This evidence concerns the gene PARD3 and cancer.