Indeed, the Gab/Grb2 interaction might be more relevant in primary tissues or immortalized cell lines such as BMMCs and MCF-10A, than in particular tumour cell lines often used in signalling studies, e.g. Jurkat or MCF-7 cells, which display elevated PIP3 levels due to the loss of PTEN expression or PIK3CA mutations, respectively [65-68]. This evidence concerns the gene A1BG and neoplasm.