Lastly, it should be mentioned that somatic missense mutations resulting in conversion of the amino acid residues Y83, T387 and R498 into C, N and M, respectively, have been identified in the human GAB1 gene in human breast and lung cancers, albeit at very low frequencies (for details see the COSMIC database at http://www.sanger.ac.uk/genetics/CGP/cosmic/ and Ref. The gene discussed is GAB1; the disease is lung cancer.