The studies of Bentires-Alj et al. [35] were complemented by a recent report from the Feng laboratory demonstrating that ablation of Gab2 severely suppresses lung metastasis of Neu-induced mammary tumours and that Neu-transformed but Gab2-deficient mammary epithelial cells exhibit decreased migration and impaired ERK activation, [216]. The gene discussed is GAB2; the disease is breast cancer.