PPARG and ischemia: To determine if pioglitazone-induced angiogenic response in STZ-diabetic mice depends on activation of PPARγ, we compared two groups of STZ-diabetic mice undergoing hindlimb ischemia with selective PPARγ agonist GW1929 (n = 10) or with pioglitazone associated with selective PPARγ inhibitor GW9662 (n = 10).