Electrophysiology on another Scn8a mouse mutant with tremor [Scn8amed−jo/Scn8amed−jo (Ala1071Thr)] showed that the Scn8amed−jo mutation caused a shift in the voltage dependence of SCN8A channel activation (Kohrman et al. 1996), which could decrease neuronal excitability and thus result in ataxia and tremor. The gene discussed is SCN8A; the disease is Ataxia.