Electrophysiology on another Scn8a mouse mutant with tremor [Scn8amed−jo/Scn8amed−jo (Ala1071Thr)] showed that the Scn8amed−jo mutation caused a shift in the voltage dependence of SCN8A channel activation (Kohrman et al. 1996), which could decrease neuronal excitability and thus result in ataxia and tremor. This evidence concerns the gene SCN8A and cerebellar ataxia.