Electrophysiology on another Scn8a mouse mutant with tremor [Scn8amed−jo/Scn8amed−jo (Ala1071Thr)] showed that the Scn8amed−jo mutation caused a shift in the voltage dependence of SCN8A channel activation (Kohrman et al. 1996), which could decrease neuronal excitability and thus result in ataxia and tremor. Here, SCN8A is linked to Tremor.