IGFBP6 and familial pancreatic carcinoma: However, over expressed IGFBP6 may be involved in maintaining the proliferative state of cells and preventing cellular differentiation in several tumors.[38, 39] Our results showed that mRNA of IGFBP6 was highly expressed in pancreatic cancer tissues and down-regulated significantly in cultured pancreatic cancer cells by cyclopamine or RNAi for Gli1.