The results showed that relative mRNA levels of Shh, Gli1, IGFBP6, PCNA, Bcl-2 and Bax mRNA were increased with 2.21-fold, 2.16-fold, 1.65-fold, 2.43-fold, 1.9-fold and 1.21-fold, respectively (p < 0.05) and at the same time the expression of IGF2 mRNA was decreased to 0.52-fold (p < 0.05) in pancreatic cancer tissues compared with cancer side tissues. Here, SHH is linked to familial pancreatic carcinoma.