Since the Shh-Gli1 signaling pathway is reactivated in pancreatic cancer, the mechanisms of Hh signaling promoting development of cancer will undoubtedly, to a great extent, depend on target genes of transcription factor Gli1.[29] It is a common distinctive characteristic of all Gli1 targets that there are highly homologous sequences to Gli1 binding site. Here, SHH is linked to familial pancreatic carcinoma.