Thus, thrombin induced IL-8 and VEGF release from prostate cancer cells[19] and IL-6 production from synovial fibroblasts[20] was blocked by siRNA of PAR-1, trypsin induced IL-8 production from human gastric epithelial cells (MKN45 cells) was inhibited by siRNA of PAR-2[21]. This evidence concerns the gene VEGFA and Familial prostate cancer.