CSF3 and Decreased total leukocyte count: Two patients underwent s.c. granulocyte-colony stimulating factor (G-CSF) administration due to the appearance of severe leukopenia and 1 patient received erithrocyte transfusion for severe anaemia all after 3 infusions; 2 patients required tracheotomy due to severe dyspnea; 1 patient was temporarily fed with a nasogastric tube; while 3 other patients were submitted to PEG for severe mucositis with odynophagia.