DKK1 and polyposis: However, it does not take an active part in the Wnt/β-catenin pathway in colon cancer cells, as mutation of adenomatous polyposis coli (one of the components of Wnt pathway) occurs in most human colon cancers [29,30], thus disconnecting the effector part of the signaling cascade from the Wnt receptors, where DKK1 exerts its inhibitory effect [31,32].