Similarly, some modes of viral infection suggest that the NPC channel widens concurrently with import of viral genetic material [5]: Viral infection often includes the nuclear import of intact capsids, as is the case with papovaviruses [6],[7] and hepatitis B virus [8], or import of the intact viral genome, as occurs with adenoviruses [9] and type-1 herpes simplex virus [5]. This evidence concerns the gene NPC1 and viral infectious disease.