It should be noted that NALP5 was also implicated as an autoantigen in autoimmune polyendocrine syndrome type 1 [47], and also that transient expression of recombinant NALP1 or NALP5 in neurons was found to induce caspase-3 activation and apoptosis [48]. This evidence concerns the gene CASP3 and autoimmune polyendocrine syndrome type 1.