The very tip of our 17q12 linkage peak occurs in AP2B1 (adaptor-related protein complex 2, beta 1 subunit), which plays a role in Nef-mediated CD8 down-regulation [43], and children with recurrent otitis media had low numbers of CD8+-producing IFN g cells in adenoids [44]. The gene discussed is CD8A; the disease is otitis media.