GSTM1 and acute chest syndrome: These results support the theory that SCD patients in Eastern province has in general a milder disease -Avascular necrosis of femoral head and splenic complications are exceptions with less frequent ACS crisis, most likely due to high prevalence of Asian haplotype among SCD patients in this area,[5, 18, 21, 27–30] coexisting alpha-thalassaemia,[31, 32] persistence of high Hb-F levels,[33, 34] haematology, social circumstances and geographical and climatic variation.[4, 35]