PCK1 and type 2 diabetes mellitus: Cao et al. [4] reported on the discovery of a single nucleotide polymorphism (SNP) in the promoter region of PCK1 (-232C/G) that was associated with T2D in Canadian Caucasian and Oji-Cree cohorts (odds ratio (OR) = 2.8, 95% CI 1.7 - 4.7, p = 4 × 10-5 and OR = 1.9, 95% CI 1.2 - 3.0, p = 9 × 10-3 respectively).