Given the importance of all pathway members in the control of hypoxia-induced gene expression, our aims were to: (1) determine the level and pattern of expression of HIF-1α, PHDs and FIH in a large cohort of familial breast cancers, (2) correlate expression with conventional clinicopathological parameters, (3) investigate expression in familial breast cancers stratified by intrinsic breast cancer phenotypes and (4) explore their role in patient survival. Here, CASR is linked to breast cancer.