PTGS2 and melanoma: In the context of melanoma, increased expression of the NFAT target gene cyclooxygenase-2 (COX-2), an inducible enzyme involved in the conversion of arachidonic acid to prostaglandins, correlates with poor prognosis (Kuzbicki et al, 2006; Chwirot and Kuzbicki, 2007), suggesting that NFAT signalling may be important in melanoma.