S100A6 and familial pancreatic carcinoma: However, the observed positive correlation in this study between high S100A6 levels and the localisation of annexin 2 to the plasma membrane in pancreatic cancer cells may have significance with respect to the ability of these cells to move, as annexin 2 has been implicated in the regulation of actin dynamics, cell spreading and wound closure (Hayes et al, 2006; Babbin et al, 2007; de Graauw et al, 2008).