Our demonstration that S100A6 and annexin 2 coimmunoprecipitate with either S100A6 or annexin 2 antibodies, along with their colocalisation within the cytoplasm and membranes of pancreatic cancer cells, suggest that S100A6 may be a significant annexin 2-binding partner in pancreatic cancer cells. Here, ANXA2 is linked to pancreatic neoplasm.