As both S100A6 and annexin 2 are overexpressed in pancreatic cancer, with expression occurring early in the development of the cancer in both cases (Sitek et al, 2005; Vimalachandran et al, 2005; Esposito et al, 2006; Ortiz-Zapater et al, 2007), we focused our attention particularly on annexin 2. This evidence concerns the gene ANXA2 and familial pancreatic carcinoma.