The cancer-associated ATP-dependent chromatin remodeling enzymes SMARCB1 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily B, member 1) and BRG1 (brahma-related gene 1), and BRM (brahma) regulate gene expression by altering nucleosome spacing [162-166]. This evidence concerns the gene SMARCB1 and cancer.