G6PC1 and Hyperglycemia: Although we did notice a mild hyperglycemia at ZT12 in Rev-KO mice (Figure S10E), the circadian expression of Phosphoenol pyruvate carboxykinase (Pepck) was nearly unaltered, and that of Glucose 6-phosphatase (G6pase) was only moderately affected (Figure S10A and S10B).