CALM1 and autosomal recessive polycystic kidney disease: ARPKD is the most common heritable cystic renal disease occurring in infancy, with mutations of a single localized gene in an area in Chromosome 6 (PHKD1).[2] PHKD1 gene is expressed at high levels in fetal and adult kidneys and at lower levels in the liver and this corresponds to the principal sites of the disease.