Further, the diminished capability of sertoli cells to phagocytize the degenerating cells was accounted to the proximity of carcinoma in situ (CIS) in testis.[17] Halley propounded the breakage of tubular basal membrane, possibly due to an immunological mechanism, to be the cause of TM.[18] Glycoproteins released from the basal membranes form the matrix and precipitation around the nidus forming microliths. The gene discussed is ART4; the disease is in situ carcinoma.