The tumor stage at diagnosis, histological features (favorable vs. unfavorable, presence of diffuse anaplasia) and patient age are the most important prognostic determinants which impact on treatment selection and oncological outcome.[18] The LOH at chromosome 1p and 16q was prospectively analyzed by NWTS-5.[19] Tumor-specific LOH for both chromosomes was found in approximately 5% of patients with FH WT and was associated with increased risk of relapse and death. Here, FH is linked to neoplasm.