There is soluble factor-dependence of STAT3 induced activity in the tumor cells-monocyte co-cultures based on the increase in STAT3 activity in monocytes when both PC3 and MCF-7 were replaced with their conditioned media (Fig. 1 and 2A, lower panels), or when monocytes and the tumor cells were on opposite sides of a transwell membrane (not shown). This evidence concerns the gene STAT3 and neoplasm.