APOE and neuroblastoma: This drug-induced effect on cholesterol transport/export was also observed in cultured human neuroblastoma cells (SH-SY5Y), with clozapine (25 μM) and haloperidol (25 μM) enhancing the expression of ApoE about 1.9-fold (p = 0.007) and 2.5-fold (p = 0.001) at 24 hours, respectively.