CASP2 and posterior cortical atrophy: To determine whether DTX-induced cytotoxicity in PCa cells is dependent on the activation of caspases, particularly caspase-2, we first examined the activity of caspases-2 and -3 in the hormone-refractory PCa cell lines PC3, DU145, and RWPE-2 after treatment with increasing DTX doses, ranging from 0.01 μM to 5 μM.