Moreover, our preclinical finding of zinc and drug combination therapy for maximal therapeutic response of cancer cells to drugs might be of general importance in light of recent work showing that treatment of cancer by anti-angiogenic agents like anti VEGFR or small molecule inhibitors of tyrosine kinase may result in hypoxia that selects for more malignant metastatic and invasive cells, that eventually lead the tumors to relapse as a more invasive and metastatic disease [45], [46]. Here, KDR is linked to metastatic neoplasm.