Nevertheless, it can be speculated that changes in the phosphorylation status of eIF4GI, eIF4E and 4E-BPs could play a more relevant role on ASFV protein synthesis during the infection of swine macrophages, the natural target of the virus, since the basal levels and activity of initiation factors have been shown to be lower in differentiated cells [56]. This evidence concerns the gene EIF4E and infection.