For example, while in teenagers a positive correlation was revealed between early ATS and Hsp60 levels [54], the picture is not clear in older individuals with symptomatic ATS, because in these older patients there are so many other variables that must be considered in relation to ATS that to make reliable correlations between plasma Hsp60 levels and disease is practically impossible. The gene discussed is HSPD1; the disease is Andersen-Tawil syndrome.