ORMDL3 and childhood onset asthma: In the first asthma GWAS, using 307,328 single nucleotide polymorphisms (SNPs), Moffatt et al. found highly statistically significant associations of SNPs in adjacent genes ORM1-like (S. cerevisiae) (ORMDL3; OMIM 610075) and gasdermin B (GSDMB or GSDML; OMIM 611221) with risk of childhood asthma in German and British populations [5].