The chromosome 9q21.31 SNP rs2378383, which is located 147 kb upstream of TLE4 in an intergenic region between coiled-coil-helix-coiled-coil-helix domain containing 9 (CHCHD9) and TLE4, was associated with childhood asthma in the replication study with p = 0.03. Here, TLE4 is linked to asthma.