CALCA and Sepsis: It has been postulated that sensory neuropeptides in general act as local growth factors.102 There is also increasing evidence that neuropeptides participate in many of the inflammatory processes that are crucial for normal wound healing.38 Plasma levels of CGRP are increased in soft tissue injuries103 and in patients with chronic cardiac failure and sepsis,104 indicating that CGRP may be another important peptide in chronic illness.