CALCA and ischemia: CGRP has a proliferative effect on human endothelial cells; therefore, it is important for the formation of new vessels, for example, in ischemia, inflammation, and the healing of wounds; it is also regarded as an important modulator of the inflammatory response after the activation of sensory nerves (Fig 1).2,12 The aim of this review article is to report the anti-inflammatory properties of CGRP in burns.