Skeletal and Muscular Disorder (8.3 × 10-7-2.70 × 10-2) involved the following genes: ANAPC2, BIN1, CDK9, CDK2AP2, FLNA, IKBKB, ITGAL, MAP2K5, MAP4K1, MCM5, NOD1, SIGIRR and USI. Here, SIGIRR is linked to muscle tissue disorder.