Homogenate of whole Spinal Cord of both sporadic and familial ALS showed differential expression of CD74, CYBA, GYS1, POLD2, ENG, SF1 (upregulated) and CAMLG, SRPK1 (downregulated) [13] and upregulation of VIL2 in a second study [23]. The gene discussed is ENG; the disease is amyotrophic lateral sclerosis.