Homogenate of whole Spinal Cord of both sporadic and familial ALS showed differential expression of CD74, CYBA, GYS1, POLD2, ENG, SF1 (upregulated) and CAMLG, SRPK1 (downregulated) [13] and upregulation of VIL2 in a second study [23]. This evidence concerns the gene POLD2 and amyotrophic lateral sclerosis.