The functional role of MGP in neoplasia remains unclear, but in line with our findings in gliomas, increased levels of MGP were found in ovarian, breast, urogenital and skin cancer [12-16], although decreased levels of MGP have been found in colon carcinoma [29], and loss of MGP expression in metastatic renal cell carcinoma and prostatic carcinoma compared with primary tumors has been associated with tumor progression and metastasis [15]. This evidence concerns the gene MGP and central nervous system cancer.