F5 and rheumatoid arthritis: In conclusion, our study highlighted several new genes (LY96/MD-2, NFAT5, TXN, CAMP/LL37, ORM1, ORM2, SLC11A1, PGLYRP1 and F5) in PBMCs of RA patients that could contribute in the identification of innovative clinical biomarkers for diagnostic procedures and therapeutic interventions.