In conclusion, our study highlighted several new genes (LY96/MD-2, NFAT5, TXN, CAMP/LL37, ORM1, ORM2, SLC11A1, PGLYRP1 and F5) in PBMCs of RA patients that could contribute in the identification of innovative clinical biomarkers for diagnostic procedures and therapeutic interventions. This evidence concerns the gene PGLYRP1 and rheumatoid arthritis.