AKT1 and rheumatoid arthritis: Other anti-apoptotic apparatuses expressed in RA FLSs include FLIP (Fas-associated death domain-like interleukin [IL]-1β-converting enzyme-inhibitory protein) [3], sentrin [4], mutated p53 [5,6], and the activation of the nuclear factor-kappa-B or the Akt signaling pathways or both [7,8].