In the case of EOCa, enhanced expression of α1-antichymotrypsin (ACT), clusterin (CLU), α1-antitrypsin (AAT) and its fragments (AATf), haptoglobin β-chain (HAP) as well as its cleaved fragments (HAPc) and leucine rich glycoprotein (LRG) was detected in serum samples of the cancer patients compared to control individuals. The gene discussed is CLU; the disease is early-onset cerebellar ataxia with retained tendon reflexes.