Our gel-based proteomic studies performed on unfractionated whole serum samples of patients with different types of cancer had demonstrated the different altered expression of selective serum high abundance acute-phase proteins (APPs) in sera of patients with EOCa [6], germ-line ovarian carcinoma [6], breast cancer [7], nasopharyngeal carcinoma [8], endometrial adenocarcinoma [9], squamous cell cervical carcinoma [9], adenocervical carcinoma [9] and osteosarcoma [10]. This evidence concerns the gene CTSB and cancer.