In the case of EOCa, enhanced expression of α1-antichymotrypsin (ACT), clusterin (CLU), α1-antitrypsin (AAT) and its fragments (AATf), haptoglobin β-chain (HAP) as well as its cleaved fragments (HAPc) and leucine rich glycoprotein (LRG) was detected in serum samples of the cancer patients compared to control individuals. This evidence concerns the gene SERPINA1 and cancer.