HK3 and ovarian neoplasm: Since the serine proteinase inhibitor is known to form a complex with human kallikrein 3 (HK3; also known as prostate-specific antigen) [27], and HK3 has been shown to be produced by a number of tumors including the ovarian tumor [28], it is very likely that the excess ACT detected in sera of the EOCa patients was part of a complex with HK3 or other proteins.