Importantly however, an increased Aβ42/Aβ40 ratio, which is typical of AD, had an inverse expression pattern of NEUROG2 and KIAA0125: A decreased Aβ42/Aβ40 ratio down-regulated NEUROG2, but up-regulated KIAA0125, whereas an increased Aβ42/Aβ40 ratio up-regulated NEUROG2, but down-regulated KIAA0125. This evidence concerns the gene FAM30A and Alzheimer disease.