In subjects without MetS, no statistically significant gender differences were observed in any other parameters measured, but in women with MetS the level of hs-CRP was 0.67 pg/mL (95% CI: 0.13 to 1.17 pg/mL, P = .013) and the level of IL-1Ra was 77 pg/mL (95% CI: 17 to 141 pg/mL, P = .014) higher than the corresponding levels seen in men. This evidence concerns the gene CRP and metabolic syndrome.