The functional relationship between Hsp-27, encoded by the gene HSPB1 located on human chromosome 7 at q11.23, and behavioural phenotype was suggested in the preliminary study that showed Hsp-27 expression to predict (P<0.0001) death from prostate cancer (Cornford et al, 2000). The gene discussed is HSPB1; the disease is Familial prostate cancer.