Our original observation that Hsp-27 predicts clinical recurrence in prostate cancer was supported by the finding from a subsequent study that the protein level increases after androgen ablation and is cytoprotective in hormone-refractory prostate cancer (Rocchi et al, 2004), and, more recently, by two studies on men undergoing radical prostatectomy (Glaessgen et al, 2008; Miyake et al, 2008). The gene discussed is HSPB1; the disease is prostate cancer.