In the univariate analyses, Hsp-27 cytoplasmic positivity was a significant prognostic factor for poor survival from prostate cancer (HR=1.89, 95% CI=1.32–2.70, P<0.001) and overall survival (HR=1.60, 95% CI=1.26–2.05, P<0.001). The gene discussed is HSPB1; the disease is Familial prostate cancer.