HSPB1 and cancer: In multivariate analyses that included Gleason score, extent of disease, baseline PSA and age at diagnosis, Hsp-27 cytoplasmic positivity remained an independent prognostic factor for poor cancer-specific survival (Δχ2(1df)=4.49, P=0.03) and overall survival (Δχ2(1df)=7.45, P=0.005).