TP53 and glioblastoma: We studied the effect of celecoxib in human glioblastoma cells with various p53 status; U87MG cells with high and low levels of p53 [by both genetic (oncoprotein E6) and pharmaceutical intervention (pifithrin-α)], LN229 (with wild type p53 function despite a p53 mutation in the coding sequence [36]) and U373MG (with mutant p53) cells.