Choi et al. (2003) have shown that RACK-1 gene expression is induced by NF-κB leading to cell survival of PC-12 cells upon withdrawal of nerve growth factor. Consistent with this, RACK-1 overexpression relieves EIA-mediated growth inhibition, protects SAOS-2 tumor cells (Sang et al., 2001) and produces resistance to dexamethasone and UV-induced apoptosis in W7.2 thymoma cells (Mourtada-Maarabouni et al., 2005). Here, RACK1 is linked to neoplasm.